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Ricolinostat

Intervention

1 paper2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Natural Science Foundation of Zhejiang Province
  • Animals1

Outcomes

2

Pyroptosis

downin mice1

1 study

  1. Ricolinostat decreases pyroptosis in mice.

    “Using ACY-1215 could reduce the activation of NLRP3 inflammasome, the pyroptosis of microglia and the degree of spatial memory impairment.”

    Animalssplenectomy under sevoflurane anesthesiahippocampusmales

    Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice

    Biochimica et biophysica acta. Molecular basis of disease23 Mar 2024

More on Pyroptosis

Spatial memory impairment

downin mice1

1 study

  1. Ricolinostat decreases spatial memory impairment in mice.

    “Using ACY-1215 could reduce the activation of NLRP3 inflammasome, the pyroptosis of microglia and the degree of spatial memory impairment.”

    Animalssplenectomy under sevoflurane anesthesiahippocampusmales

    Hippocampal HDAC6 promotes POCD by regulating NLRP3-induced microglia pyroptosis via HSP90/HSP70 in aged mice

    Biochimica et biophysica acta. Molecular basis of disease23 Mar 2024

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