Retrorsine

1. Retrorsine induces cellular senescence in mouse cells.

   “RTS increased intracellular ROS levels and β-galactosidase activity of HPC-enriched liver oranoids in vitro”

   Cellsliver

   Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy

   Annals of medicine·3 Mar 2026

More on Cellular senescence

1. Retrorsine increases oxidative stress and ROS signalling in mouse cells.

   “RTS increased intracellular ROS levels and β-galactosidase activity of HPC-enriched liver oranoids in vitro”

   Cellsliver

   Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy

   Annals of medicine·3 Mar 2026

More on Oxidative stress and ROS signalling

1. Retrorsine decreases liver-to-body weight ratio in mice.

   “By day 14 post-PH, the 70 mg/kg RTS/PH mice exhibited reduced liver-to-body weight ratios compared to control mice, indicating regeneration failureafter PH.”

   Animalsafter partial hepatectomyliver70 mg/kgday 14 post-PH

   Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy

   Annals of medicine·3 Mar 2026

More on Liver-to-body weight ratio

1. Retrorsine inhibits hepatocyte proliferation in mice.

   “RTS 0-70 mg/kg dose-dependently reduced the PCNA+ hepatocyte ratio on day 2 post-PH with hepatocyte proliferation completely suppressed by 70 mg/kg RTS.”

   Animalsafter partial hepatectomyliver0-70 mg/kgday 2 post-PH

   Retrorsine impairs liver regeneration by inducing progenitor cell-senescence via ROS after partial hepatectomy

   Annals of medicine·3 Mar 2026