Resolvin D2

1 paper3 findings

PubChem ChEBI MeSH

1 lab in 1 country

Funders: National Heart, Lung, and Blood Institute and 1 more

Animals1

Outcomes

3

Senescent macrophage clearance

upin mouse cells1

1 study

Resolvin D2 increases senescent macrophage clearance in mouse cells.
“RvD2 enhanced the clearance of senescent macrophages but knockdown or blockade of CD24 and CD47 were also required for efficient clearance.”
Cellsin vitro
Resolvin D2 limits senescent cell accumulation in atherosclerotic plaques
Vascular pharmacology5 Aug 2025

Cleaved CASPASE-3

upin mouse cells1

1 study

Resolvin D2 increases cleaved CASPASE-3 in mouse cells.
“RvD2 treatment to senescent macrophages in vitro increased Cleaved Caspase-3 (an apoptosis marker)”
Cellsin senescent macrophages in vitro
Resolvin D2 limits senescent cell accumulation in atherosclerotic plaques
Vascular pharmacology5 Aug 2025

More on Cleaved CASPASE-3

Senescent cell accumulation

downin mice1

1 study

Resolvin D2 decreases senescent cell accumulation in mice.
“RvD2 treatment in Ldlr-/- mice led to decreased accumulation of senescent cells in plaques.”
Animalsin Ldlr-/- miceatherosclerotic plaque
Resolvin D2 limits senescent cell accumulation in atherosclerotic plaques
Vascular pharmacology5 Aug 2025

More on Senescent cell accumulation

Latest

1 in 12 months

FASEB Journal1 Dec

Vascular Bed-Specific Endothelial Dysfunction and Age-Dependent Circadian Hypertension in Mice Lacking the Resolvin D2 Receptor GPR18

Experiments in miceMechanisms

Vascular Pharmacology5 Aug

Resolvin D2 limits senescent cell accumulation in atherosclerotic plaques

Experiments in miceAtherosclerosis

The American Journal of Pathology18 Sep

Resolvin D2-G-Protein Coupled Receptor 18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging

Experiments in animalsInterventions