REP8839

1. REP8839 activates autophagy in worms.

   “These compounds also trigger a significant upregulation of autophagy, specifically at their lifespan-extending doses.”

   Model organisms

   Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in C. elegans

   Biomolecules·1 Jan 2026

More on Autophagy

1. REP8839 improves healthspan in worms.

   “REP8839, REP3123, LysRS-In-2, and halofuginone, that extend both healthspan and lifespan in C. elegans”

   Model organisms

   Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in C. elegans

   Biomolecules·1 Jan 2026

1. REP8839 extends lifespan in worms.

   “REP8839, REP3123, LysRS-In-2, and halofuginone, that extend both healthspan and lifespan in C. elegans”

   Model organisms

   Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in C. elegans

   Biomolecules·1 Jan 2026