Refined-ingredient diet

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Center for Advancing Translational Sciences and 3 more

Animals1

Outcomes

Butyrate

downin rats1

1 study

Refined-ingredient diet decreases butyrate in rats.
“butyrate, a microbial-derived short-chain fatty acid, was rapidly and robustly depleted in both gut and circulation, especially in aged animals”
Animalsmales
The aged amygdala's unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis
Brain, behavior, and immunity9 Dec 2025

Latest

1 in 12 months

Brain, Behavior, and Immunity12 Dec

The aged amygdala's unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis

Experiments in ratsMechanisms

Paper

Refined-ingredient diet

Outcomes

Latest

The aged amygdala's unique sensitivity to refined diets, independent of fat or sugar content: A brain region and cell type-specific analysis

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