Recombinant IGFBP7

Recombinant IGFBP7 has been studied in 2 papers since 2024: 2 observational studies in people; 1 in the past year. The newest story, Nov 7, 2026: “Mice lacking a protein released by cells had lower blood pressure”.

Intervention

2 papers study it2 findingsUpdated Nov 2, 2026

1 new paper in 30 daysSee all 2 papers on recombinant IGFBP7

At a glance

The findings reach mice, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

2 independent labs in 1 country

Funder: National Natural Science Foundation of China

Humans2

What did studies of recombinant IGFBP7 find?

Studies of recombinant IGFBP7 measured 2 outcomes; the most studied are endothelium-dependent relaxation (1 study) and cellular senescence (1).

Endothelium-dependent relaxation

downin mice1

1 study

Recombinant IGFBP7 impairs endothelium-dependent relaxation in mice (Ex vivo acetylcholine-induced relaxation) (95.5±1.8% vs. 66.7±8.5%).
“acute rIGFBP7 exposure impaired ACh-induced endothelium-dependent relaxation (95.5±1.8% vs. 66.7±8.5%, p<0.05)”
AnimalsEx vivo acetylcholine-induced relaxationrecombinant proteinmesenteric arteryacute
Mice lacking a protein released by cells had lower blood pressure
AHA Scientific Sessions 2026 abstractNov 2, 2026

Cellular senescence

downin human cells1

1 study

Recombinant IGFBP7 decreases cellular senescence in H2O2-induced DPFs.
“Recombinant IGFBP7 reduced the senescence of H2O2-induced DPFs.”
Cellsin H2O2-induced DPFs
Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA sequencing
Journal of advanced researchDec 12, 2024

Latest

1 paper in 12 months

AHA Scientific Sessions 2026 AbstractNov 7

Mice lacking a protein released by cells had lower blood pressure

Genetically altered mice also had lower levels of aldosterone, a hormone involved in blood pressure control, than unmodified controls.Genetically altered mice also had lower levels of aldosterone, a hormone involved in blood pressure control, than unmodified controls.

Mouse studyMechanisms