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RAAV-YME1L

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Natural Science Foundation of China and 1 more
  • Animals1

Outcomes

2

Renal dysfunction

downin mice1

1 study

  1. RAAV-YME1L decreases renal dysfunction in mice.

    “tubule-specific overexpression of YME1L significantly alleviated RTEC senescence and renal dysfunction in the HFD/STZ-induced DKD mouse model”

    Animalsin HFD/STZ-induced DKD micekidney

    YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

    Biological research17 Mar 2024

Cellular senescence

downin mice1

1 study

  1. RAAV-YME1L decreases cellular senescence in mice.

    “tubule-specific overexpression of YME1L significantly alleviated RTEC senescence and renal dysfunction in the HFD/STZ-induced DKD mouse model”

    Animalsin HFD/STZ-induced DKD micekidney

    YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

    Biological research17 Mar 2024

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