Psychological resilience

Exposure

5 papers5 findings

  • 4 independent labs in 3 countries
  • Funders: Bill and Melinda Gates Foundation and 6 more
  • Humans5

Associations

5

Regional brain age gap

upin humans1

1 study
  1. Psychological resilience is associated with regional brain age gap in humans.

    “Follow-up tests showed the CD-RISC x Group interaction was only significant in the subcortical region”

    Humanssubcortical region, in women with PTSDsubcortical regionfemales

    The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women

    Neuroscience9 Feb 2026

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Brain age gap

upin humans1

1 study
  1. Psychological resilience is associated with brain age gap in humans.

    “higher CD-RISC scores were associated with a positive brain age gap (reflecting an older appearing brain) only in women with suspected PTSD”

    Humansin women with suspected PTSDfemales

    The moderating role of psychological resilience on brain aging and PTSD in a community sample of South African women

    Neuroscience9 Feb 2026

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Cognitive frailty

downin humans1

1 study
  1. Psychological resilience lowers the risk of cognitive frailty in humans (RRR=0.91, 95% CI: 0.90, 0.93).

    “A 1-point increase in PR score reduced cognitive frailty risk by 9% (RRR=0.91, 95% CI: 0.90, 0.93)”

    Humans

    Psychological resilience and cognitive frailty progression among older adults: Evidence from China in 2002-2018

    GSA 2025 abstract31 Dec 2025

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Frailty

downin humans1

1 study
  1. Psychological resilience lowers the risk of frailty in humans (β = -.093, p <.05).

    “Older adults with high psychological resilience were less likely to develop frailty (β = -.093, p <.05)”

    Humansn = 1,397

    PERCEIVED STRESS AS A MEDIATOR OF THE ASSOCIATION BETWEEN PSYCHOLOGICAL RESILIENCE AND FUNCTIONAL DECLINES

    GSA 2024 abstract31 Dec 2024

Frailty improvement

upin humans1OR 1.28

1 study
  1. Psychological resilience is associated with frailty improvement in humans (adjusted OR, 1.28 [95% CI, 1.05 to 1.57]).

    “A similar association was observed between PR and frailty improvement (adjusted odds ratio [OR], 1.28 [95% CI, 1.05 to 1.57]).”

    Humans

    Psychological Resilience and Frailty Progression in Older Adults

    JAMA network open4 Nov 2024

Funding

1 grant since 2023

National Institute on AgingUS$186.5k

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