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PRE-084

Intervention

1 paper3 findings

PubChem 126402ChEBI 93007

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Key Science and Technology Program of Shaanxi Province and 1 more
  • Animals1

Outcomes

3

Inflammation

downin mice1

1 study

  1. PRE-084 decreases inflammation in mice.

    “mitigation of neuroinflammation, indicated by decreased microglial and astrocytic activation, inhibition of NF-κB activation”

    Animalsafter exploratory laparotomyhippocampus

    Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation

    International immunopharmacology11 Oct 2025

More on Inflammation

ER unfolded protein response

downin mice1

1 study

  1. PRE-084 decreases ER unfolded protein response in mice.

    “These salutary effects were associated with an attenuation of endoplasmic reticulum (ER) stress, evidenced by reduced levels of BIP and p-eIF2α”

    Animalsafter exploratory laparotomyhippocampus

    Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation

    International immunopharmacology11 Oct 2025

More on ER unfolded protein response

Cognitive function

upin mice1

1 study

  1. PRE-084 improves cognitive function in mice.

    “Post-surgical administration of PRE-084 to aged mice resulted in a substantial amelioration of cognitive function, as assessed by the Morris water maze.”

    Animalsafter exploratory laparotomyhippocampus

    Sigma-1 receptor activation ameliorates age-related postoperative cognitive dysfunction by attenuating endoplasmic reticulum stress and neuroinflammation

    International immunopharmacology11 Oct 2025

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