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Positive-pressure ventilation

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Alfred P. Sloan Foundation and 7 more
  • Animals1

Outcomes

1

Capillary compression

upin mice1

1 study

  1. Positive-pressure ventilation increases capillary compression in mice.

    “differing effects of ventilation mode (i.e., positive vs. negative) present themselves at the capillary level, with vessels under positive pressure undergoing more compression than when under negative-pressure conditions.”

    Animalslung

    Micromechanics of lung capillaries across mouse lifespan and in positive- vs negative-pressure ventilation

    npj biological physics and mechanics3 Sep 2025

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