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Polyphenol-rich diet

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and others
  • Human trial1

Outcomes

3

Microbiome composition

upin humans1

1 study

  1. Polyphenol-rich diet improves microbiome composition in humans.

    “Distinct microbial shifts were observed, including an increase in Blautia and Dorea and a modest improvement in microbial diversity in cH subjects.”

    Human trialhigh baseline inflammation8 weeks

    Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome

    Microbiome research reports21 Oct 2025

More on Microbiome composition

C-reactive protein

downin humans1

1 study

  1. Polyphenol-rich diet decreases C-reactive protein in humans.

    “The PR-diet was associated with a significant reduction in key inflammatory markers [e.g., interleukin-6 (IL-6), C-reactive protein] in the cH group.”

    Human trialhigh baseline inflammation8 weeks

    Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome

    Microbiome research reports21 Oct 2025

More on C-reactive protein

IL-6

downin humans1

1 study

  1. Polyphenol-rich diet decreases IL-6 in humans.

    “The PR-diet was associated with a significant reduction in key inflammatory markers [e.g., interleukin-6 (IL-6), C-reactive protein] in the cH group.”

    Human trialhigh baseline inflammation8 weeks

    Effect of a polyphenol-rich dietary pattern on subjects aged ≥ 60 years with higher levels of inflammatory markers: insights into microbiome and metabolome

    Microbiome research reports21 Oct 2025

More on IL-6

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