Pistacia lentiscus

1. Pistacia lentiscus induces transcriptomic changes related to endothelial junction organization and vascular integrity in humans.

   “In high-risk participants, mastic supplementation induced distinct transcriptomic changes, particularly in pathways related to endothelial junction organization and vascular integrity.”

   Human trialpredefined high-risk subgroup with well-controlled hypertension3 months

   Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial

   Pharmacology research & perspectives·16 Oct 2026

More on Transcriptomic changes related to endothelial junction organization and vascular integrity

1. Pistacia lentiscus has no effect on proteasome concentration in humans.

   “Oxidative stress markers and proteasome activity remained unchanged across groups.”

   Human trialstable, well-controlled hypertensionperipheral blood mononuclear cells and red blood cells1500 or 2800 mg/day3 monthsn = 106

   Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial

   Pharmacology research & perspectives·16 Oct 2026

More on Proteasome concentration

1. Pistacia lentiscus has no effect on oxidative stress markers in humans.

   “Oxidative stress markers and proteasome activity remained unchanged across groups.”

   Human trialstable, well-controlled hypertension1500 or 2800 mg/day3 monthsn = 106

   Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial

   Pharmacology research & perspectives·16 Oct 2026

More on Oxidative stress markers

1. Pistacia lentiscus has no effect on 24-h ambulatory systolic and diastolic blood pressure in humans.

   “No significant between-group differences were observed in 24-h systolic or diastolic blood pressure after the intervention.”

   Human trialstable, well-controlled hypertension; compared with placebo1500 or 2800 mg/day3 monthsn = 106

   Chios Mastic in Well-Controlled Hypertension: Findings From the HYPER-MASTIC Randomized Controlled Trial

   Pharmacology research & perspectives·16 Oct 2026