Peripherally trephinated descemet membrane endothelial keratoplasty

1. Peripherally trephinated descemet membrane endothelial keratoplasty has no effect on secondary graft failure in humans (5.9% vs 10.8%, P = 0.13).

   “SGF occurred more frequently in DMEK-cD (10.8%) than DMEK-pD (5.9%), although the difference was not statistically significant (P = 0.13).”

   Human trialin eyes with corneal endothelial dysfunctioncornea5 yearsn = 428

   Five-Year Endothelial Cell Density Outcomes After DMEK Using Peripherally Versus Centrally Trephinated Donor Tissue

   Cornea·9 Jul 2026

More on Secondary graft failure

1. Peripherally trephinated descemet membrane endothelial keratoplasty has no effect on corrected distance visual acuity in humans (P = 0.15).

   “Visual acuity improvement was comparable between groups (P = 0.15).”

   Human trialin eyes with corneal endothelial dysfunctioncornea5 yearsn = 428

   Five-Year Endothelial Cell Density Outcomes After DMEK Using Peripherally Versus Centrally Trephinated Donor Tissue

   Cornea·9 Jul 2026

1. Peripherally trephinated descemet membrane endothelial keratoplasty increases endothelial cell density in humans (1534 ± 279 vs 1280 ± 394 cells/mm2 at 5 years, P < 0.001).

   “Mean ECD was significantly higher in the DMEK-pD group at all postoperative time points: 2368 ± 224 versus 2024 ± 312 cells/mm2 at 6 months, 1942 ± 284 versus 1698 ± 352 cells/mm2 at 2 years, and 1534 ± 279 versus 1280 ± 394 cells/mm2 at 5 years (all P < 0.001).”

   Human trialin eyes with corneal endothelial dysfunctioncornea5 yearsn = 428

   Five-Year Endothelial Cell Density Outcomes After DMEK Using Peripherally Versus Centrally Trephinated Donor Tissue

   Cornea·9 Jul 2026

More on Endothelial cell density