Fuchs endothelial corneal dystrophy

1 paper3 findings

Humans1

Associations

2

Polygenic risk score

upin humans1OR 1.37

1 study

Polygenic risk score raises the risk of Fuchs endothelial corneal dystrophy in humans (OR = 1.37).
Humansin Europeans without large STR expansions
Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy
Investigative ophthalmology & visual science3 Aug 2026
Polygenic risk score predicts Fuchs endothelial corneal dystrophy in humans (AUC 0.83 (95% CI, 0.82-0.84)).
Humansin European validation cohorts
Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy
Investigative ophthalmology & visual science3 Aug 2026

More on Polygenic risk score

TCF4

upin humans1

1 study

TCF4 raises the risk of Fuchs endothelial corneal dystrophy in humans (OR = 54, AUC = 0.89).
Humans>40 repeats in All of Us
Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy
Investigative ophthalmology & visual science3 Aug 2026

Trial sponsors

Massachusetts Eye and Ear Infirmary
1 trialPhase 245 people

Latest

1 in 12 months

Investigative Ophthalmology & Visual Science17 Aug

Genome-Wide Association Study of Corneal Dystrophy Uncovers Novel Risk Loci and Enables Improved Polygenic Prediction of Fuchs Endothelial Corneal Dystrophy

Study in peopleBiomarkers