Secondary graft failure

1. Peripherally trephinated descemet membrane endothelial keratoplasty has no effect on secondary graft failure in humans (5.9% vs 10.8%, P = 0.13).

   “SGF occurred more frequently in DMEK-cD (10.8%) than DMEK-pD (5.9%), although the difference was not statistically significant (P = 0.13).”

   Human trialin eyes with corneal endothelial dysfunctioncornea5 yearsn = 428

   Five-Year Endothelial Cell Density Outcomes After DMEK Using Peripherally Versus Centrally Trephinated Donor Tissue

   Cornea·9 Jul 2026

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