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P53 and lsd1/kdm1a inhibition

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 1 more
  • Humans1

Outcomes

1

Mitotic rejuvenation

upin human cells1

1 study

  1. P53 and lsd1/kdm1a inhibition improves mitotic rejuvenation in human cells.

    “dual inhibition of p53 and LSD1/KDM1A in aged cells, we mitigate the reduction in centromeric proteins and centromeric transcripts, leading to the mitotic rejuvenation of these cells”

    Cells

    Centromere inactivation during aging can be rescued in human cells

    Molecular cellJan 13, 2025

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