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P16-POSITIVE senescent cell clearance

Exposure

1 paper studies it2 findings

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Center for Cell Signaling in Gastroenterology, Mayo Clinic and 8 more
  • Animals1

Outcomes

2

Cognitive function

upin animals1

1 study

  1. P16-POSITIVE senescent cell clearance improves cognitive function.

    “clearance in female p16-InkAttac mice, which is associated with preservation of cognitive function.”

    Animalsgenetic clearancebrainfemales

    Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

    Nature communications

Activated resident and infiltrating immune cells

downin animals1

1 study

  1. P16-POSITIVE senescent cell clearance decreases activated resident and infiltrating immune cells.

    “Activated resident and infiltrating immune cells increase in the aged brain and are partially restored to youthful levels through p16-positive senescent cell clearance in female p16-InkAttac mice”

    Animalsgenetic clearancebrainfemales

    Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

    Nature communications

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