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Oxysterol

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Institute on Aging
  • 2 of 2 findings with company ties
  • Cells1

Outcomes

1

CXCR4-dependent signalling

downin cells1

1 study

  1. Oxysterol impairs CXCR4-dependent signalling in cells.

    “Tail-oxidized sterols disrupted signalling more than ring-oxidized counterparts.”

    Cellscompared with ring-oxidized sterolstail-oxidized sterols

    Oxysterol accumulation in aging cells alters GPCR signalling

    bioRxiv (Cold Spring Harbor Laboratory)14 May 2024Preprint

Associations

1

G-protein coupling specificity

mixedin cells1

1 study

  1. Oxysterol is associated with G-protein coupling specificity in cells.

    “the presence of oxysterols, which switched G-protein signalling from Gα i/o to Gα s class.”

    Cellsswitch from Gα i/o to Gα s class

    Oxysterol accumulation in aging cells alters GPCR signalling

    bioRxiv (Cold Spring Harbor Laboratory)14 May 2024Preprint

Funding

1 grant since 2023

National Institute on AgingUS$1.9m

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