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Opn-mi micelles

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Beijing Municipal Natural Science Foundation and 1 more
  • Animals1

Outcomes

4

MMP9

downin mice1

1 study

  1. Opn-mi micelles decrease MMP9 in mice.

    “OPN-MI micelles reduced MMP9 expression (p = 0.001) through SIRT6 deacetylation.”

    Animalsaorta

    Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging

    Aging medicine (Milton (N.S.W))26 Oct 2025

More on MMP9

Intimal-medial thickness

downin mice1

1 study

  1. Opn-mi micelles decrease intimal-medial thickness in mice.

    “the intimal-medial thickness in the OPN-MI micelles group was alleviated (p = 0.048)”

    Animalsaorta8 weeks

    Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging

    Aging medicine (Milton (N.S.W))26 Oct 2025

Elastin breaks

downin mice1

1 study

  1. Opn-mi micelles decrease elastin breaks in mice.

    “the number of elastin breaks in the OPN-MI micelles group was reduced (p = 0.016)”

    Animalsaorta8 weeks

    Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging

    Aging medicine (Milton (N.S.W))26 Oct 2025

Pulse wave velocity

downin mice1

1 study

  1. Opn-mi micelles decrease pulse wave velocity in mice.

    “PWV of abdominal aortas in the OPN-MI micelles group decreased (p = 0.031)”

    Animalsaorta8 weeks

    Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging

    Aging medicine (Milton (N.S.W))26 Oct 2025

More on Pulse wave velocity

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