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Omigapil

Intervention

1 paper4 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 4 of 4 findings with company ties
  • Animals1

Outcomes

4

Cell death

downin mice1

1 study

  1. Omigapil protects against cell death in mice.

    “rescued facial motor neuron cell bodies in rat pups after axotomy, rat hippocampal CA1 neurons after transient ischemia/hypoxia, and mouse nigral dopaminergic cell bodies from death induced by MPTP”

    AnimalsMPTP-induced neurotoxicitysubstantia nigra0.0003 and 0.1 mg/kg p.o. or s.c.

    Neurorescuing effects of the GAPDH ligand CGP 3466B

    Journal of neural transmission. Supplementum1 Jan 2000

Motor function

upin rats1

1 study

  1. Omigapil improves motor function in rats.

    “improved motor function in these animals.”

    Animals6-OHDA-lesioned rats

    Neurorescuing effects of the GAPDH ligand CGP 3466B

    Journal of neural transmission. Supplementum1 Jan 2000

Motor performance

upin mice1

1 study

  1. Omigapil improves motor performance in mice.

    “preserved their body weight and improved their motor performance.”

    Animalsprogressive motor neuronopathy (pmn) mice (a model for ALS)

    Neurorescuing effects of the GAPDH ligand CGP 3466B

    Journal of neural transmission. Supplementum1 Jan 2000

Lifespan

upin mice1

1 study

  1. Omigapil extends lifespan in mice.

    “Moreover, it prolonged the life-span of progressive motor neuronopathy (pmn) mice (a model for ALS), preserved their body weight and improved their motor performance.”

    Animalsprogressive motor neuronopathy (pmn) mice (a model for ALS)

    Neurorescuing effects of the GAPDH ligand CGP 3466B

    Journal of neural transmission. Supplementum1 Jan 2000

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