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Oleuropein aglycone

Intervention

1 paper4 findings

PubChem 56842347ChEBI 139162MeSH C000625725

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Agència de Gestió d'Ajuts Universitaris i de Recerca and 7 more
  • Model organisms1

Outcomes

4

Dopaminergic neuronal loss

downin worms1

1 study

  1. Oleuropein aglycone decreases dopaminergic neuronal loss in worms.

    “recovered dopaminergic neuronal loss”

    Model organismsα-synuclein overexpressiondopaminergic neuron

    Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

    Molecular neurobiology24 Jul 2025

Motor function

upin worms1

1 study

  1. Oleuropein aglycone improves motor function in worms.

    “improved motor defects”

    Model organismsα-synuclein overexpression

    Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

    Molecular neurobiology24 Jul 2025

Healthspan

upin worms1

1 study

  1. Oleuropein aglycone improves healthspan in worms.

    “oleuropein aglycone administration was beneficial for healthspan and lifespan in animals overexpressing α-synuclein”

    Model organismsα-synuclein overexpression

    Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

    Molecular neurobiology24 Jul 2025

Lifespan

upin worms1

1 study

  1. Oleuropein aglycone extends lifespan in worms.

    “oleuropein aglycone administration was beneficial for healthspan and lifespan in animals overexpressing α-synuclein”

    Model organismsα-synuclein overexpression

    Oleuropein Aglycone, an Olive Polyphenol, Influences Alpha-Synuclein Aggregation and Exerts Neuroprotective Effects in Different Parkinson's Disease Models

    Molecular neurobiology24 Jul 2025

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