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OKN-007

Intervention

1 paper3 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 2 more
  • Animals1

Outcomes

3

Mitochondrial function

upin mice1

1 study

  1. OKN-007 improves mitochondrial function in mice.

    “Mitochondrial function was improved by OKN-007 treatment, consistent with its potential antioxidative properties.”

    Animalsmuscle8-9 monthsmales

    Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice

    GeroScience21 Mar 2024

More on Mitochondrial function

Muscle mass

no changein mice1

1 study

  1. OKN-007 has no effect on muscle mass in mice.

    “In contrast, OKN-007 treatment provided no protection in loss of muscle mass in aging mice.”

    Animals8-9 monthsmales

    Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice

    GeroScience21 Mar 2024

Muscle force generation

upin mice1+25%

1 study

  1. OKN-007 improves muscle force generation in mice (~ 25%).

    “The loss in muscle force generation in aging mice (~ 25%) is significantly improved with OKN-007 treatment.”

    Animals8-9 monthsmales

    Neuroprotective treatment with the nitrone compound OKN-007 mitigates age-related muscle weakness in aging mice

    GeroScience21 Mar 2024

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