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Night shift cessation

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro
  • Humans1

Outcomes

2

Epigenetic age

downin humans1

1 study

  1. Night shift cessation decreases epigenetic age in humans (β = -0.08, p=0.05).

    “Additionally, TL increased and AA decreased with each year since night shift cessation (β = 0.01, p=0.001 and β = -0.08, p=0.05, respectively).”

    Humanswith each year since night shift cessation

    Impact of night shift work on telomere length and epigenetic age in older workers

    Journal of occupational medicine and toxicology (London, England)1 Oct 2025

More on Epigenetic age

Telomere length

upin humans1

1 study

  1. Night shift cessation increases telomere length in humans (β = 0.01, p=0.001).

    “Additionally, TL increased and AA decreased with each year since night shift cessation (β = 0.01, p=0.001 and β = -0.08, p=0.05, respectively).”

    Humanswith each year since night shift cessation

    Impact of night shift work on telomere length and epigenetic age in older workers

    Journal of occupational medicine and toxicology (London, England)1 Oct 2025

More on Telomere length

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