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Nicotinamide + pyridoxine

Intervention

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: Nestlé Health Science and 3 more
  • 2 of 3 findings with company ties
  • Animals1

Outcomes

4

Biochemistry

upin humans1

1 study

  1. Nicotinamide + pyridoxine improves biochemistry in humans.

    “both patients were treated with oral nicotinamide (a B3 vitamer and NAD+ precursor) and pyridoxine (a vitamin B6, cofactor of KYNU) from young age, which improved biochemistry”

    Human trialin KYNU deficiencyoral

    Two new cases of KYNU deficiency: Further delineation of the phenotypic and biochemical spectrum and exploration of treatment options

    Molecular genetics and metabolismJul 19, 2025

Muscle stem cell function

upin mice1

1 study

  1. Nicotinamide + pyridoxine improves muscle stem cell function in mice.

    “The combination of the two compounds promoted MuSC function in vivo in aged mice”

    Review

    The muscle stem cell case of Benjamin Button: rejuvenating muscle regenerative capacity through nutraceuticals

    The Journal of clinical investigationDec 16, 2024

Muscle strength

upin animals1

1 study

  1. Nicotinamide + pyridoxine increases muscle strength.

    “increased muscle strength during recovery, and overcame MuSC dysfunction and regenerative failure during aging.”

    Animals

    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging

    The Journal of clinical investigationNov 12, 2024

Muscle regeneration

upin animals1

1 study

  1. Nicotinamide + pyridoxine improves muscle regeneration.

    “Oral treatment with a combination of NAM and PN accelerated muscle regeneration in vivo by stimulating MuSCs, increased muscle strength during recovery, and overcame MuSC dysfunction and regenerative failure during aging.”

    Animals

    Nicotinamide and pyridoxine stimulate muscle stem cell expansion and enhance regenerative capacity during aging

    The Journal of clinical investigationNov 12, 2024

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