Neural stem cells

1. Neural stem cells extend lifespan in mice (+56%).

   “A small number of grafted cells ( approximately 3000) increased the life span of the mice by 56%.”

   Animalspmn micelumbar spinal cordapproximately 3000 cells

   Grafted neural stem cells increase the life span and protect motoneurons in pmn mice

   Neuroreport·17 Sep 2007

2. Neural stem cells extend lifespan in rats (>10 days).

   “extended the lifespan of these animals by more than 10 days”

   AnimalsSOD1 G93A transgenic modellumbar cord

   Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats

   Transplantation·15 Oct 2006

1. Neural stem cells increase muscle fiber size in mice.

   “an increase in the size of the muscle fibers.”

   Animalspmn mice

   Grafted neural stem cells increase the life span and protect motoneurons in pmn mice

   Neuroreport·17 Sep 2007

1. Neural stem cells improve body weight in mice.

   “a stabilization in the weight and an increase in the size of the muscle fibers.”

   Animalspmn mice

   Grafted neural stem cells increase the life span and protect motoneurons in pmn mice

   Neuroreport·17 Sep 2007

1. Neural stem cells protect against motoneuron count in mice.

   “The improved survival was accompanied by a rescue of host motoneurons”

   Animalspmn micelumbar spinal cord

   Grafted neural stem cells increase the life span and protect motoneurons in pmn mice

   Neuroreport·17 Sep 2007

More on Motoneuron count

1. Neural stem cells lower the risk of motor neuron disease in rats.

   “NSC grafts delayed the onset and progression of the fulminant motor neuron disease typical of the rat SOD1 G93A model”

   AnimalsSOD1 G93A transgenic modellumbar cord

   Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats

   Transplantation·15 Oct 2006

More on Motor neuron disease