N-methyl-d-aspartate

1. N-methyl-d-aspartate increases neurogenesis in mice.

   “N-methyl-D-aspartate-induced retinal injury further promoted the acquisition of neurogenic competence toward inner nuclear layer neuronal identities.”

   Animalswith Plagl2 in adult mouse retinaretina

   Plagl2 unlocks the latent regenerative potential of Müller glia in the adult mouse retina

   bioRxiv (Cold Spring Harbor Laboratory)·21 Apr 2026Preprint

1. N-methyl-d-aspartate increases taurine release in mice.

   “N-methyl-D-aspartate (NMDA), kainate and 2-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) potentiated taurine release concentration-dependently at each age”

   Animalshippocampus

   Taurine release from the developing and ageing hippocampus: stimulation by agonists of ionotropic glutamate receptors

   Mechanisms of ageing and development·30 Dec 1997

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1. N-methyl-d-aspartate increases gonadotropin-releasing hormone in rats.

   “whereas N-methyl-D-Aspartate (NMDA) and kainate appeared more efficacious in young and old rats, respectively.”

   Animalshypothalamic explantshypothalamusmales

   Different responses of gonadotropin-releasing hormone (GnRH) release to glutamate receptor agonists during aging

   Brain research bulletin·1 Jan 1996

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