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Myristic acid

Intervention

3 papers study it1 more mentions it8 findings

PubChemChEBI

Across all fields, 3 papers: none in people yet, 3 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Guangzhou University of Chinese Medicine and 3 more
  • Animals2
  • Model organisms1

Outcomes

8

Osteoclast differentiation

downin mouse cells1

1 study

  1. Myristic acid inhibits osteoclast differentiation in mouse cells.

    “MA notably inhibited osteoclast activity, as evidenced by a decrease in the number of osteoclasts and a significant suppression of F-actin formation”

    Cellsinduced by RANKLRAW264.7

    Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice

    Frontiers in pharmacology

Cellular senescence

downin mouse cells1

1 study

  1. Myristic acid decreases cellular senescence in mouse cells.

    “MA postponed the senescence of TBHP-induced endplate chondrocytes”

    CellsTBHP-inducedendplate chondrocytes

    Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice

    Frontiers in pharmacology

More on Cellular senescence

Osteoporosis

downin mice1

1 study

  1. Myristic acid decreases osteoporosis in mice.

    “MA tended to improve vertebral osteoporosis and endplate osteochondral remodeling”

    Animalsintraperitoneal injection2 mg/kg·d2 months

    Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice

    Frontiers in pharmacology

More on Osteoporosis

Intervertebral disc degeneration

downin mice1

1 study

  1. Myristic acid decreases intervertebral disc degeneration in mice.

    “alleviated IDD in naturally aged mice”

    Animalsintraperitoneal injection2 mg/kg·d2 months

    Myristic acid beneficially modulates intervertebral disc degeneration by preventing endplate osteochondral remodeling and vertebral osteoporosis in naturally aged mice

    Frontiers in pharmacology

More on Intervertebral disc degeneration

GABRA2

upin mice1

1 study

  1. Myristic acid increases GABRA2 in mice.

    “upregulated GABRA2 expression”

    Animalsnaturally agedhippocampus

    Myristic acid alleviates hippocampal aging correlated with GABAergic signaling

    Frontiers in nutrition

More on GABRA2

GABRB2

downin mice1

1 study

  1. Myristic acid decreases GABRB2 in mice.

    “MA downregulated GABRB2”

    Animalsnaturally agedhippocampus

    Myristic acid alleviates hippocampal aging correlated with GABAergic signaling

    Frontiers in nutrition

More on GABRB2

Hippocampal neuron degeneration

downin mice1

1 study

  1. Myristic acid decreases hippocampal neuron degeneration in mice.

    “ameliorated degeneration and aging of hippocampal neurons”

    Animalsnaturally agedhippocampus

    Myristic acid alleviates hippocampal aging correlated with GABAergic signaling

    Frontiers in nutrition

Spatial memory

upin mice1

1 study

  1. Myristic acid improves spatial memory in mice.

    “MA alleviated the damage of exploration and spatial memory ability”

    Animalsnaturally agedhippocampus

    Myristic acid alleviates hippocampal aging correlated with GABAergic signaling

    Frontiers in nutrition

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