Multivitamin-multimineral
Intervention1 paper3 findings
- Human trial1
Outcomes
3Oligomeric amyloid-beta
no changein humans1High certainty
1 study
Oligomeric amyloid-beta
no changein humans1High certainty
Multivitamin-multimineral has no effect on oligomeric amyloid-beta in humans (-8.9%; 95% CI: -23.9% to 9%; p = 0.31).
Human trial2 years
Effect of a multivitamin and cocoa flavanol extract on changes in neurofilament light, N-terminal tau fragment, and oligomeric amyloid-β levels in COSMOS-clinic · Journal of Alzheimer's disease : JAD · 23 Sep 2026
NfL
no changein humans1High certainty
1 study
NfL
no changein humans1High certainty
Multivitamin-multimineral has no effect on NfL in humans (3.1%; 95% CI: -1.9% to 8.3%; p = 0.23).
Human trial2 years
Effect of a multivitamin and cocoa flavanol extract on changes in neurofilament light, N-terminal tau fragment, and oligomeric amyloid-β levels in COSMOS-clinic · Journal of Alzheimer's disease : JAD · 23 Sep 2026
N-terminal tau fragment
no changein humans1High certainty
1 study
N-terminal tau fragment
no changein humans1High certainty
Multivitamin-multimineral has no effect on N-terminal tau fragment in humans (3.7%; 95% CI: -3% to 10.8%; p = 0.29).
Human trial2 years
Effect of a multivitamin and cocoa flavanol extract on changes in neurofilament light, N-terminal tau fragment, and oligomeric amyloid-β levels in COSMOS-clinic · Journal of Alzheimer's disease : JAD · 23 Sep 2026