Multicomponent intervention
Intervention3 papers7 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funders: Universidad de Zaragoza and others
- Human trial3
Outcomes
6Tinetti balance score
downin humans1
1 study
Tinetti balance score
downin humans1
Multicomponent intervention decreases Tinetti balance score in humans.
Human trialin older adults with intellectual disabilitytwo-year follow-up
Cognitive, functional and psychological aging in adults with and without intellectual disability and its evolution over time with a multicomponent program: Prospective longitudinal study · Geriatric nursing (New York, N.Y.) · 17 Sep 2026
Praxis
downin humans1
1 study
Praxis
downin humans1
Multicomponent intervention impairs praxis in humans.
Human trialin older adults without intellectual disabilitytwo-year follow-up
Cognitive, functional and psychological aging in adults with and without intellectual disability and its evolution over time with a multicomponent program: Prospective longitudinal study · Geriatric nursing (New York, N.Y.) · 17 Sep 2026
Cognitive function
upin humans1
1 study
Cognitive function
upin humans1
Multicomponent intervention improves cognitive function in humans.
Human trialin older adults without intellectual disabilitytwo-year follow-up
Cognitive, functional and psychological aging in adults with and without intellectual disability and its evolution over time with a multicomponent program: Prospective longitudinal study · Geriatric nursing (New York, N.Y.) · 17 Sep 2026
Time free from mobility disability or death
upin humans1
1 study
Time free from mobility disability or death
upin humans1
Multicomponent intervention improves time free from mobility disability or death in humans (2.09 months).
Human trialfrailty, sarcopenia and two or more chronic conditionsn = 1,199
Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial · Nature aging · 31 Aug 2026
Frailty severity
downin humans1
1 study
Frailty severity
downin humans1
Multicomponent intervention decreases frailty severity in humans (decreased in 74% of participants).
Human trialin remission from cancer6 monthsn = 81
Improvement of frailty and prefrailty in older cancer survivors: a 6-month home-based pilot study · Age and ageing · 3 Aug 2026
Frailty
downin humans1−62% improved frailty status
1 study
Frailty
downin humans1−62% improved frailty status
Multicomponent intervention decreases frailty in humans (62% improved frailty status).
Human trialin remission from cancer6 monthsn = 81
Improvement of frailty and prefrailty in older cancer survivors: a 6-month home-based pilot study · Age and ageing · 3 Aug 2026
Associations
1Mobility disability or death
downin humans1HR 0.78
1 study
Mobility disability or death
downin humans1HR 0.78
Multicomponent intervention lowers the risk of mobility disability or death in humans (HR 0.78, 95% CI 0.66-0.92).
Human trialfrailty, sarcopenia and two or more chronic conditionsn = 1,199
Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial · Nature aging · 31 Aug 2026