Multi-ingredient nutraceuticals

1. Multi-ingredient nutraceuticals decrease IL-6 secretion in mouse cells.

   “reducing nuclear size, ROS release, and IL-6 secretion in senescent fibroblasts.”

   Cellssenescent fibroblasts12 pro-longevity natural compoundsfibroblast

   Rescuing Healthspan in Obese, Aged Mice: A Comparison between Multi-Ingredient Nutraceuticals and Senolytic Interventions

   Preprints.org·31 Dec 2025Preprint

More on IL-6 secretion

1. Multi-ingredient nutraceuticals protect against cognitive function in mice.

   “Cognitive performance was preserved in nutraceutical-treated mice”

   Animalsoverweight, naturally aged C57Bl/6J mice12 pro-longevity natural compoundscontinuous treatmentmales

   Rescuing Healthspan in Obese, Aged Mice: A Comparison between Multi-Ingredient Nutraceuticals and Senolytic Interventions

   Preprints.org·31 Dec 2025Preprint

1. Multi-ingredient nutraceuticals decrease frailty progression in mice.

   “Both interventions improved survival compared to controls (median lifespan +18–21%) and mitigated frailty progression”

   Animalsoverweight, naturally aged C57Bl/6J mice12 pro-longevity natural compoundscontinuous treatmentmales

   Rescuing Healthspan in Obese, Aged Mice: A Comparison between Multi-Ingredient Nutraceuticals and Senolytic Interventions

   Preprints.org·31 Dec 2025Preprint

1. Multi-ingredient nutraceuticals extend lifespan in mice (+18–21% median lifespan across the two interventions versus controls).

   “Both interventions improved survival compared to controls (median lifespan +18–21%)”

   Animalsoverweight, naturally aged C57Bl/6J mice following a switch to soaked food12 pro-longevity natural compoundscontinuous treatmentmales

   Rescuing Healthspan in Obese, Aged Mice: A Comparison between Multi-Ingredient Nutraceuticals and Senolytic Interventions

   Preprints.org·31 Dec 2025Preprint