Mntnbuoe-2-pyp5+

1. Mntnbuoe-2-pyp5+ has no effect on lifespan in flies.

   “Neither compound improves lifespan in parkin-null flies.”

   Model organismsparkin-null flies

   Manganese Porphyrin Reduces Oxidative Stress in Vulnerable Parkin-Null Drosophila Dopaminergic Neurons

   Antioxidants (Basel, Switzerland)·22 Aug 2025

2. Mntnbuoe-2-pyp5+ extends lifespan in flies.

   “both compounds reduce an oxidative stress marker at the whole-brain level and extend lifespan in control flies”

   Model organismscontrol flies

   Manganese Porphyrin Reduces Oxidative Stress in Vulnerable Parkin-Null Drosophila Dopaminergic Neurons

   Antioxidants (Basel, Switzerland)·22 Aug 2025

1. Mntnbuoe-2-pyp5+ decreases hydrogen peroxide in flies.

   “MnTnBuOE-2-PyP5+ reduces hydrogen peroxide levels in mitochondria of dopaminergic neurons”

   Model organismsparkin-null fliesdopaminergic neurons

   Manganese Porphyrin Reduces Oxidative Stress in Vulnerable Parkin-Null Drosophila Dopaminergic Neurons

   Antioxidants (Basel, Switzerland)·22 Aug 2025

More on Hydrogen peroxide

1. Mntnbuoe-2-pyp5+ improves motivated behavior in flies.

   “MnTnBuOE-2-PyP5+, improves developmental deficits and motivated behavior in female flies”

   Model organismsparkin-null fliesfemales

   Manganese Porphyrin Reduces Oxidative Stress in Vulnerable Parkin-Null Drosophila Dopaminergic Neurons

   Antioxidants (Basel, Switzerland)·22 Aug 2025