ML346

  • 1 lab in 1 country
  • Funders: National Health Commission of the People's Republic of China and 1 more
  • Animals1

Outcomes

2

Bone mass loss

downin mice1

1 study
  1. ML346 decreases bone mass loss in mice.

    “the exacerbated protein aggregation and bone mass loss in Nsun2 -deficient mice were ameliorated following treatment with the molecular chaperone activator-ML346.”

    AnimalsNsun2-deficient micebone

    Aberrant 5-Methylcytosine tRNA Modification Disrupts Proteostasis and Exacerbates Age-Related Osteoporosis

    bioRxiv (Cold Spring Harbor Laboratory)5 Nov 2025Preprint

Protein aggregation

downin mice1

1 study
  1. ML346 decreases protein aggregation in mice.

    “the exacerbated protein aggregation and bone mass loss in Nsun2 -deficient mice were ameliorated following treatment with the molecular chaperone activator-ML346.”

    AnimalsNsun2-deficient mice

    Aberrant 5-Methylcytosine tRNA Modification Disrupts Proteostasis and Exacerbates Age-Related Osteoporosis

    bioRxiv (Cold Spring Harbor Laboratory)5 Nov 2025Preprint

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