tRNA m5C

1 paper1 finding

Animals1

Upstream

1

NSUN2

upin mice1

1 study

NSUN2 increases tRNA m5C in mice.
“age-dependent Nsun2 downregulation in BMSCs reduces m5C levels of tRNAs”
Animalsage-dependent Nsun2 downregulationbone marrow stromal cell
Aberrant 5-Methylcytosine tRNA Modification Disrupts Proteostasis and Exacerbates Age-Related Osteoporosis
bioRxiv (Cold Spring Harbor Laboratory)5 Nov 2025Preprint

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bioRxiv5 Nov

Aberrant 5-Methylcytosine tRNA Modification Disrupts Proteostasis and Exacerbates Age-Related Osteoporosis

Preprint: experiments in miceProteostasis