Mitochondrial epigenetic editor

1. Mitochondrial epigenetic editor decreases mt-Nd4 expression in mice.

   “leading to reduced MT-ND4 expression in the targeted brain region and altered plasma levels of t-Tau and NFL in mice.”

   AnimalsMethylation targeting C11168 (H)targeted brain region

   Programmable aging function-related mitochondrial DNA 5-methylcytosine (m5C) modification with a TALE-directed methyltransferase

   Cell communication and signaling : CCS·27 Jun 2026

More on mt-Nd4 expression

1. Mitochondrial epigenetic editor increases C11168 (H) methylation in mice (11.76% increase).

   “MEE increased methylation at the aging-associated C11168 (H) site by 11.76% in vivo”

   Animals

   Programmable aging function-related mitochondrial DNA 5-methylcytosine (m5C) modification with a TALE-directed methyltransferase

   Cell communication and signaling : CCS·27 Jun 2026

More on C11168 (H) methylation