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Minimally processed diet

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Institute of Food and Agriculture and 2 more
  • Human trial1

Outcomes

4

FGF21

upin humans1

1 study

  1. Minimally processed diet increases FGF21 in humans (Δ+65 vs Δ+88 pg/mL, p < 0.026).

    “FGF21 increased (Δ+65 vs Δ+88 pg/mL MPP vs MPL) in both diet phases (all, p < 0.026 BSL vs post-diet”

    Human trial8 weeksn = 36

    Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

    Clinical nutrition (Edinburgh, Scotland)29 Oct 2025

More on FGF21

Fat mass

downin humans1

1 study

  1. Minimally processed diet decreases fat mass in humans (Δ-2.6 vs Δ-2.9 kg).

    “and fat mass (Δ-2.6 vs Δ-2.9 kg).”

    Human trial8 weeksn = 36

    Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

    Clinical nutrition (Edinburgh, Scotland)29 Oct 2025

Body weight

downin humans1

1 study

  1. Minimally processed diet decreases body weight in humans (Δ-3.8 vs Δ-4.4 kg).

    “resulting in reductions in body weight (Δ-3.8 vs Δ-4.4 kg), and fat mass (Δ-2.6 vs Δ-2.9 kg).”

    Human trial8 weeksn = 36

    Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

    Clinical nutrition (Edinburgh, Scotland)29 Oct 2025

HOMA-IR

downin humans1

1 study

  1. Minimally processed diet decreases HOMA-IR in humans (p < 0.038).

    “Both diets improved HOMA-IR, insulin, C-peptide, total cholesterol, LDL, apolipoprotein B, non-HDL, and CRP relative to BSL (all, p < 0.038 BSL vs post-diet”

    Human trial8 weeksn = 36

    Impacts of minimally-processed omnivorous vs lacto-ovo-vegetarian diets on insulin sensitivity, lipid profile, and adiposity in older adults: Secondary findings from a randomized crossover feeding trial

    Clinical nutrition (Edinburgh, Scotland)29 Oct 2025

More on HOMA-IR

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