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Mevastatin

Intervention

2 papers4 findings

PubChem 64715ChEBI 34848MeSH C012258

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 2 countries
  • Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 6 more
  • Cells2

Outcomes

4

RAC1

upin human cells1

1 study

  1. Mevastatin activates RAC1 in human cells.

    “mevastatin induced a migratory phenotype in primary human keratinocytes through EGF-mediated activation of Rac1”

    CellsEGF-mediated

    Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling

    JCI insight5 Dec 2019

More on RAC1

EGFR

upin human cells1

1 study

  1. Mevastatin activates EGFR in human cells.

    “mevastatin activated and modulated the EGF signaling to trigger an antiproliferative and promigratory phenotype”

    Cells

    Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling

    JCI insight5 Dec 2019

More on EGFR

Keratinocyte migration

upin human cells1

1 study

  1. Mevastatin increases keratinocyte migration in human cells.

    “Mevastatin restored EGF signaling in DFUs through disruption of caveolae to promote keratinocyte migration”

    Cells

    Mevastatin promotes healing by targeting caveolin-1 to restore EGFR signaling

    JCI insight5 Dec 2019

TERF2

upin human cells1

1 study

  1. Mevastatin increases TERF2 in human cells (>3-fold).

    “atorvastatin (0.1 micromol/L) and mevastatin (1.0 micromol/L) both led to a more than 3-fold increase in the expression of the telomere capping protein TRF2”

    Cellsin cultured EPCs1.0 micromol/L

    Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells

    Circulation1 Nov 2004

More on TERF2

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