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Metformin-engineered extracellular vesicles

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Science and Technology Commission of Shanghai Municipality and 2 more
  • Animals1

Outcomes

6

Mitophagy

upin mice1

1 study

  1. Metformin-engineered extracellular vesicles increase mitophagy in mice.

    “We show Met-EV rescue senescence-induced mitochondria dysfunctions and mitophagy suppressions”

    Animalssenescence-induced mitophagy suppression

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

More on Mitophagy

Mitochondrial function

upin mice1

1 study

  1. Metformin-engineered extracellular vesicles improve mitochondrial function in mice.

    “We show Met-EV rescue senescence-induced mitochondria dysfunctions and mitophagy suppressions”

    Animalssenescence-induced mitochondrial dysfunction

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

Oxidative phosphorylation

upin mice1

1 study

  1. Metformin-engineered extracellular vesicles increase oxidative phosphorylation in mice.

    “Notably, ATP metabolism was remodeled as reduced glycolysis and enhanced OXPHOS after Met-EV treatment.”

    Animals

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

More on Oxidative phosphorylation

Glycolysis

downin mice1

1 study

  1. Metformin-engineered extracellular vesicles decrease glycolysis in mice.

    “Notably, ATP metabolism was remodeled as reduced glycolysis and enhanced OXPHOS after Met-EV treatment.”

    Animals

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

More on Glycolysis

Cellular senescence

downin mice1

1 study

  1. Metformin-engineered extracellular vesicles decrease cellular senescence in mice.

    “metformin engineered EV (Met-EV) can enhance aged mouse skin repair, as well as ameliorate cellular senescence and restore cell dysfunctions.”

    Animalsskin

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

More on Cellular senescence

Skin wound repair

upin mice1

1 study

  1. Metformin-engineered extracellular vesicles improve skin wound repair in mice.

    “Our data show that metformin engineered EV (Met-EV) can enhance aged mouse skin repair”

    Animalsskin

    Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

    Science advances12 Apr 2024

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