Metformin-capped silver nanoparticles

Intervention1 paper4 findings

Animals1

Outcomes

4

Pyroptosis

downin human cells1Very low certainty

1 study

Metformin-capped silver nanoparticles inhibit pyroptosis in human cells.
Cellsin KGN cells treated with macrophage conditioned medium
Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency · International immunopharmacology · 30 Aug 2026

NLRP3 inflammasome

downin rats1Very low certainty

1 study

Metformin-capped silver nanoparticles inhibit NLRP3 inflammasome in rats.
Animalsin POI rats
Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency · International immunopharmacology · 30 Aug 2026

NLRP3 inflammasome →

Fertility

upin rats1Very low certainty

1 study

Metformin-capped silver nanoparticles improve fertility in rats.
Animalsin POI rats
Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency · International immunopharmacology · 30 Aug 2026

Premature ovarian insufficiency

downin rats1Very low certainty

1 study

Metformin-capped silver nanoparticles decrease premature ovarian insufficiency in rats.
Animalsin POI rats
Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency · International immunopharmacology · 30 Aug 2026

Premature ovarian insufficiency →

Latest

1

International ImmunopharmacologyAnimals30 Aug

Targeting the macrophage-NLRP3 inflammasome-pyroptosis axis: Metformin-capped silver nanoparticles as a novel therapy for premature ovarian insufficiency

Reproductive system