Meglumine

1. Meglumine decreases proinflammatory cytokine and cell adhesion molecule secretion in mouse cells.

   “high-dose meglumine limited secretion of proinflammatory cytokines and cell adhesion molecules from activated human THP-1 or murine RAW264.7 monocytes.”

   Cellsactivated monocytesRAW264.7 monocyteshigh-dose

   Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine

   Journal of cellular biochemistry·Feb 27, 2019

2. Meglumine decreases proinflammatory cytokine and cell adhesion molecule secretion in human cells.

   “high-dose meglumine limited secretion of proinflammatory cytokines and cell adhesion molecules from activated human THP-1 or murine RAW264.7 monocytes.”

   Cellsactivated monocytesTHP-1 monocyteshigh-dose

   Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine

   Journal of cellular biochemistry·Feb 27, 2019

More on Proinflammatory cytokine and cell adhesion molecule secretion

1. Meglumine decreases skin tumor incidence (Trend toward lower incidence, number, and growth).

   “the incidence, number, and growth of skin tumors trended lower in subjects receiving meglumine.”

   Animalstransgenic model of inflammation-associated skin carcinogenesisskin

   Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine

   Journal of cellular biochemistry·Feb 27, 2019

More on Skin tumor incidence

1. Meglumine has no effect on cardiac function in mice.

   “showed no detrimental effects on ejection fraction, fractional shortening, left ventricle function or volume, and cardiac output in mice up to 15-month old”

   AnimalsC57BL/6 micein drinking waterheart18 to 75 mM

   Preclinical study of the long-range safety and anti-inflammatory effects of high-dose oral meglumine

   Journal of cellular biochemistry·Feb 27, 2019