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Mdl 72527

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Japan Society for the Promotion of Science
  • Cells1

Outcomes

2

DNA damage response

downin human cells1

1 study

  1. Mdl 72527 decreases DNA damage response in human cells.

    “DNA damage accumulated in aged cells and MDL72527 reduced DNA damage.”

    Cellsin aged HepG2 cells

    Inhibition of Polyamine Catabolism Reduces Cellular Senescence

    International journal of molecular sciencesAug 29, 2023

More on DNA damage response

Cellular senescence

downin human cells1

1 study

  1. Mdl 72527 decreases cellular senescence in human cells.

    “Senescence-associated β-gal activity was increased in aged cells, and the increase was suppressed by MDL72527”

    Cellsin aged HepG2 cells

    Inhibition of Polyamine Catabolism Reduces Cellular Senescence

    International journal of molecular sciencesAug 29, 2023

More on Cellular senescence

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