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Maltreatment

Maltreatment has been studied in 2 papers since 2022: 2 observational studies in people; 1 in the past year. The newest story, Oct 21, 2026: “Childhood adversity patterns linked to poorer aging in China”.

Exposure

2 papers study it3 findingsUpdated

“the Maltreatment pattern showed no significant longitudinal association.”
Association of adverse childhood experiences patterns with successful aging trajectories: a prospective cohort studyBMC geriatrics2026doi:10.1186/s12877-026-08034-0

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: National Center for Advancing Translational Sciences and 8 more
  • Humans2

What did studies of Maltreatment find?

2

Studies of Maltreatment measured 2 outcomes; the most studied are successful aging trajectory (1 study) and GrimAge (1).

Successful aging trajectory

no changein humans1

1 study

  1. Maltreatment has no effect on successful aging trajectory in humans.

    “the Maltreatment pattern showed no significant longitudinal association.”

    HumansCompared with the Low Adversity patternEight yearsn = 3,092

    Childhood adversity patterns linked to poorer aging in China

    BMC geriatrics

GrimAge

no changein humans1

1 study

  1. Maltreatment has no effect on GrimAge in humans.

    “dimension of Maltreatment is associated with epigenetic age acceleration (EAA) using the PhenoAge but not the GrimAge clock.”

    Humansunmedicated somatically healthy adults with moderate to severe major depressionn = 82

    Dimensions of childhood adversity differentially affect biological aging in major depression

    Translational psychiatry

More on GrimAge

What is Maltreatment linked with?

1

Studies link Maltreatment with 1 measure, most often PhenoAge (1 study).

PhenoAge

upin humans1

1 study

  1. Maltreatment is associated with PhenoAge in humans (β = 0.272, p = 0.013).

    “Maltreatment is associated with epigenetic age acceleration (EAA) using the PhenoAge but not the GrimAge clock.”

    Humansunmedicated somatically healthy adults with moderate to severe major depressionn = 82

    Dimensions of childhood adversity differentially affect biological aging in major depression

    Translational psychiatry

More on PhenoAge

Funding

2 grants since 2018

National Institute on AgingUS$5.1mNational Institute of Child Health and Human DevelopmentUS$674k

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 1Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months
BMC Geriatrics

Childhood adversity patterns linked to poorer aging in China

The odds of persistently low successful aging were 1.97 times as high with widespread childhood adversity as with low adversity.The odds of persistently low successful aging were 1.97 times as high with widespread childhood adversity as with low adversity.

Cohort · 3,092 peoplePopulations
Paper

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