Magnesium aspartate hydrochloride

Magnesium aspartate hydrochloride has been studied in 6 papers since 1985: 6 trials in people. The newest paper, Mar 1, 2011: “Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial”.

Intervention

6 papers study it17 findingsUpdated Mar 1, 2011

PubChem

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“NIPTS was significantly more frequent and more severe in the placebo group than in the magnesium group, especially in bilateral damages.”

Oral magnesium intake reduces permanent hearing loss induced by noise exposureAmerican journal of otolaryngology1994doi:10.1016/0196-0709(94)90036-1

None of its findings points the other way.

6 independent labs in 7 countries

Human trial6

Studies in people

See all 6

6 studies gave magnesium aspartate hydrochloride to people and measured what changed.

down: Decreases fasting plasma glucose
up: Improves insulin sensitivity
no change: Has no effect on blood pressure
Randomized trial6 months
In normomagnesemic, overweight, insulin resistant, non-diabetic subjects
Diabetes, obesity & metabolism, Mar 1, 2011
down: Decreases diastolic blood pressure-3.4 mm Hg (95% CI 1.3, 5.6; P = 0.003)
up: Increases urinary magnesium excretion+50%
Randomized trial91 peopleWomenmiddle-aged and elderly6 mo
Midlife adults; Older adults; Patient cohorts
The American journal of clinical nutrition, Jul 1, 1994
down: Decreases noise-induced hearing loss
Randomized trial300 peopleyoung2 months
General population
American journal of otolaryngology, Jan 1, 1994
no change: Has no effect on blood pressure
no change: Has no effect on serum lipids
Randomized trial13 people3 mo
In magnesium-replete patients with mild hypertension
The American journal of clinical nutrition, Apr 1, 1990
no change: Has no effect on blood pressure
up: Increases urinary magnesium4.4 +/- 0.6 to 6.1 +/- 1 mmol/day P less than 0.001
up: Increases urinary calcium4.3 +/- 0.7 to 5.5 +/- 0.9 mmol/day P less than 0.01
Randomized trial8 weeks
Mild hypertensive subjects on a moderately low sodium diet
Clinical and experimental pharmacology & physiology, Apr 1, 1989

What did studies of Magnesium aspartate hydrochloride find?

Studies of Magnesium aspartate hydrochloride measured 13 outcomes; the most studied are blood pressure (4 studies), urinary magnesium (2) and lipid profile (1).

Blood pressure

no changein humans4

4 studies

Magnesium aspartate hydrochloride has no effect on blood pressure in humans.
“Blood pressure and lipid profile did not show significant changes.”
Human trialin normomagnesemic, overweight, insulin resistant, non-diabetic subjects6 months
Oral magnesium supplementation reduces insulin resistance in non-diabetic subjects - a double-blind, placebo-controlled, randomized trial
Diabetes, obesity & metabolismMar 1, 2011
Magnesium aspartate hydrochloride has no effect on blood pressure in humans.
“magnesium aspartate therapy had no effect on blood pressure, lipid concentrations, or erythrocyte cation metabolism.”
Human trialin magnesium-replete patients with mild hypertension40 mmol Mg aspartate (20 mmol elemental Mg twice daily)3 mon = 13
Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension
The American journal of clinical nutritionApr 1, 1990
Magnesium aspartate hydrochloride has no effect on blood pressure in humans.
“There was no fall in blood pressure with magnesium supplementation and no significant difference in blood pressure between groups at the end of the study.”
Human trialmild hypertensive subjects on a moderately low sodium diet8 weeks
Magnesium supplementation in mild hypertensive patients on a moderately low sodium diet
Clinical and experimental pharmacology & physiologyApr 1, 1989
Magnesium aspartate hydrochloride has no effect on blood pressure in humans.
“there was no fall in blood pressure compared with either treatment with placebo or values before treatment”
Human trialessential hypertension15 mmol magnesium/dayone monthn = 17
Lack of effect of oral magnesium on high blood pressure: a double blind study
British medical journal (Clinical research ed.)Jul 27, 1985

Urinary magnesium

upin humans2

2 studies

Magnesium aspartate hydrochloride increases urinary magnesium in humans (4.4 +/- 0.6 to 6.1 +/- 1 mmol/day P less than 0.001).
“In the magnesium group there was an increase in urinary magnesium (4.4 +/- 0.6 to 6.1 +/- 1 mmol/day P less than 0.001)”
Human trialmild hypertensive subjects on a moderately low sodium dieturine10 mmol/day8 weeks
Magnesium supplementation in mild hypertensive patients on a moderately low sodium diet
Clinical and experimental pharmacology & physiologyApr 1, 1989
Magnesium aspartate hydrochloride increases urinary magnesium in humans.
“significant increase in urinary excretion of magnesium while taking magnesium aspartate”
Human trialessential hypertension15 mmol magnesium/dayone monthn = 17
Lack of effect of oral magnesium on high blood pressure: a double blind study
British medical journal (Clinical research ed.)Jul 27, 1985