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Machine-based isometric axial compression

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Australian Government and 2 more
  • Human trial1

Outcomes

1

Five-times sit-to-stand time

upin humans1

1 study

  1. Machine-based isometric axial compression improves five-times sit-to-stand time in humans (-4.5 ± 1.6% vs 7.5 ± 2.0%).

    “IAC improved lean mass (0.8 ± 0.8%; -2.4 ± 0.9%, p = .013) and FTSTS (-4.5 ± 1.6%; 7.5 ± 2.0%, p < .001) compared with CON.”

    Human trialosteopenia or osteoporosis / low BMDmalesn = 93

    A Comparison of Bone-Targeted Exercise Strategies to Reduce Fracture Risk in Middle-Aged and Older Men with Osteopenia and Osteoporosis: LIFTMOR-M Semi-Randomized Controlled Trial

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research30 Mar 2020

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