Limonin

1. Limonin inhibits STAT3 in mice.

   “Lim binds to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (STAT3), inhibiting its activity”

   Animalsliver

   Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·25 Apr 2026

More on STAT3

1. Limonin decreases LGALS3 in mice.

   “while suppressing galectin-3 expression and mechanistic target of rapamycin complex 1 (mTORC1) activation.”

   AnimalsMASHliver

   Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·25 Apr 2026

More on LGALS3

1. Limonin decreases cellular senescence in mice.

   “Lim effectively alleviates hepatic fibrosis and senescence in MASH mice”

   AnimalsMASHliver

   Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·25 Apr 2026

More on Cellular senescence

1. Limonin decreases liver fibrosis in mice.

   “Lim effectively alleviates hepatic fibrosis and senescence in MASH mice”

   AnimalsMASHliver

   Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling

   Phytomedicine : international journal of phytotherapy and phytopharmacology·25 Apr 2026

More on Liver fibrosis