Leukocyte-rich platelet-rich plasma

Intervention

1 paper4 findings

  • 1 lab in 1 country
  • Funder: Gachon University
  • Animals1

Outcomes

4

Collagen fiber deposition

upin mice1

1 study
  1. Leukocyte-rich platelet-rich plasma increases collagen fiber deposition in mice.

    “In aged mice, intradermal L-PRP injections elicited dose-dependent increases in fibroblast proliferation, collagen fiber deposition, and skin elasticity.”

    Animalsintradermal injectionsskin

    Leukocyte-Rich Platelet-Rich Plasma (L-PRP) Promotes Rejuvenation of Senescent Fibroblasts and Dermal Remodeling via CCL1-CCR8 Signaling and PKM2 Modulation

    International journal of molecular sciences15 Jul 2026

Skin elasticity

upin mice1

1 study
  1. Leukocyte-rich platelet-rich plasma improves skin elasticity in mice.

    “In aged mice, intradermal L-PRP injections elicited dose-dependent increases in fibroblast proliferation, collagen fiber deposition, and skin elasticity.”

    Animalsintradermal injectionsskin

    Leukocyte-Rich Platelet-Rich Plasma (L-PRP) Promotes Rejuvenation of Senescent Fibroblasts and Dermal Remodeling via CCL1-CCR8 Signaling and PKM2 Modulation

    International journal of molecular sciences15 Jul 2026

Collagen types I and III

upin human cells1

1 study
  1. Leukocyte-rich platelet-rich plasma increases collagen types I and III in human cells.

    “These molecular events augmented the synthesis of collagen types I and III in senescent fibroblasts.”

    Cellsin senescent human dermal fibroblastsdermis

    Leukocyte-Rich Platelet-Rich Plasma (L-PRP) Promotes Rejuvenation of Senescent Fibroblasts and Dermal Remodeling via CCL1-CCR8 Signaling and PKM2 Modulation

    International journal of molecular sciences15 Jul 2026

More on Collagen types I and III

Nuclear translocation of PKM2 dimers

upin human cells1

1 study
  1. Leukocyte-rich platelet-rich plasma increases nuclear translocation of PKM2 dimers in human cells.

    “In senescent human dermal fibroblasts, L-PRP increased CCL1-CCR8 interactions in a manner linked to enhanced formation and nuclear translocation of PKM2 dimers.”

    Cellsin senescent human dermal fibroblastsdermis

    Leukocyte-Rich Platelet-Rich Plasma (L-PRP) Promotes Rejuvenation of Senescent Fibroblasts and Dermal Remodeling via CCL1-CCR8 Signaling and PKM2 Modulation

    International journal of molecular sciences15 Jul 2026

More on Nuclear translocation of PKM2 dimers

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