Leucine-enriched milk protein

Leucine-enriched milk protein has been studied in 1 paper since 2018: 1 trial in people. The newest paper, Feb 1, 2018: “Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial”.

Intervention

1 paper studies it2 findingsUpdated

See all 1 papers on leucine-enriched milk protein

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“Acute myoPS increased in response to feeding in the rested (CON: 13% ± 4%; LEU: 53% ± 5%) and exercised (CON: 30% ± 4%; LEU: 87% ± 7%) leg in both groups, but the increase was greater in LEU (P < 0.001)”
Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trialThe American journal of clinical nutrition2018doi:10.1093/ajcn/nqx028

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.
  • 1 lab in 1 country
  • Funder: PepsiCo
  • 2 of 2 findings with company ties
  • Human trial1

Studies in people

1 study gave leucine-enriched milk protein to people and measured what changed.

What changedDesignPeopleSource

up: Increases myofibrillar protein synthesis raterested: 53% ± 5% vs 13% ± 4%; exercised: 87% ± 7% vs 30% ± 4%

up: Increases integrated myofibrillar protein synthesis raterested: 9% ± 1%; exercised: 17% ± 2%

Randomized trialWomen65-75 yOlder adults; acute response to feeding, compared with isonitrogenous mixed-protein beverageThe American journal of clinical nutrition, Feb 1, 2018

What did studies of leucine-enriched milk protein find?

2

Studies of leucine-enriched milk protein measured 2 outcomes: integrated myofibrillar protein synthesis rate and myofibrillar protein synthesis rate.

Integrated myofibrillar protein synthesis rate

upin humans1

1 study
  1. Leucine-enriched milk protein increases integrated myofibrillar protein synthesis rate in humans (integrated daily response, compared with isonitrogenous mixed-protein beverage) (rested: 9% ± 1%; exercised: 17% ± 2%).

    “Integrated myoPS increased during the supplementation period in both legs (rested: 9% ±1%; exercised: 17% ± 2%; P < 0.001) in LEU, but in the exercised leg only (7% ± 2%; P < 0.001) in CON”

    Human trialintegrated daily response, compared with isonitrogenous mixed-protein beverageskeletal muscle15 g protein, 4.2 g leucine, twice dailyfemales

    Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial

    The American journal of clinical nutrition

More on Integrated myofibrillar protein synthesis rate

Myofibrillar protein synthesis rate

upin humans1

1 study
  1. Leucine-enriched milk protein increases myofibrillar protein synthesis rate in humans (acute response to feeding, compared with isonitrogenous mixed-protein beverage) (rested: 53% ± 5% vs 13% ± 4%; exercised: 87% ± 7% vs 30% ± 4%).

    “Acute myoPS increased in response to feeding in the rested (CON: 13% ± 4%; LEU: 53% ± 5%) and exercised (CON: 30% ± 4%; LEU: 87% ± 7%) leg in both groups, but the increase was greater in LEU (P < 0.001)”

    Human trialacute response to feeding, compared with isonitrogenous mixed-protein beverageskeletal muscle15 g protein, 4.2 g leucine, twice dailyfemales

    Protein leucine content is a determinant of shorter- and longer-term muscle protein synthetic responses at rest and following resistance exercise in healthy older women: a randomized, controlled trial

    The American journal of clinical nutrition

More on Myofibrillar protein synthesis rate

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