Leu-tyr-ala

1. Leu-tyr-ala decreases acn-1 in worms.

   “Leu-Tyr-Ala down-regulated the messenger RNA (mRNA) expression of acn-1 (a homolog of mammalian ACE in C. elegans)”

   Model organisms

   ACE-inhibitory peptide Leu-Tyr-Ala in skeletal muscle actin exhibits anti-aging effects through the inhibition of acn-1 in Caenorhabditis elegans

   Journal of the science of food and agriculture·14 May 2026

More on acn-1

1. Leu-tyr-ala decreases lipofuscin in worms.

   “reduced fat accumulation, and decreased lipofuscin levels in C. elegans.”

   Model organisms

   ACE-inhibitory peptide Leu-Tyr-Ala in skeletal muscle actin exhibits anti-aging effects through the inhibition of acn-1 in Caenorhabditis elegans

   Journal of the science of food and agriculture·14 May 2026

More on Lipofuscin

1. Leu-tyr-ala improves locomotor activity in worms.

   “The treatment of Leu-Tyr-Ala also improved locomotor activity, enhanced resistance to oxidative and thermal stress, reduced fat accumulation, and decreased lipofuscin levels in C. elegans.”

   Model organisms

   ACE-inhibitory peptide Leu-Tyr-Ala in skeletal muscle actin exhibits anti-aging effects through the inhibition of acn-1 in Caenorhabditis elegans

   Journal of the science of food and agriculture·14 May 2026

1. Leu-tyr-ala extends lifespan in worms (+26% average lifespan).

   “The average lifespan of C. elegans treated with 5 mmol/L Leu-Tyr-Ala was 26% longer than that of the control group.”

   Model organisms5 mmol/L

   ACE-inhibitory peptide Leu-Tyr-Ala in skeletal muscle actin exhibits anti-aging effects through the inhibition of acn-1 in Caenorhabditis elegans

   Journal of the science of food and agriculture·14 May 2026