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LCL768

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Cancer Institute and 5 more
  • Animals1

Outcomes

1

Sensorimotor deficits

upin mice1

1 study

  1. LCL768 improves sensorimotor deficits in mice.

    “Reinstituting mitophagy using a ceramide analog drug with selenium conjugate, LCL768, restored mitophagy and reduced malate/fumarate metabolism, improving sensorimotor deficits in old p17/PERMIT-/- mice.”

    Animalsin old p17/PERMIT-/- mice

    Alterations of lipid-mediated mitophagy result in aging-dependent sensorimotor defects

    Aging cell

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