LB-100

1 paper2 findings

1 lab in 1 country

Funders: Fundamental Research Funds for the Central Universities and 1 more

Animals1

Outcomes

2

Cognitive function

upin mice1

1 study

LB-100 improves cognitive function in mice.
“Pharmacological inhibition of PP2A with LB-100 restored ribosome biogenesis, prevented neuronal senescence, and rescued cognitive deficits and neurodegenerative phenotypes in PS-NP-exposed mice.”
Animalsin PS-NP-exposed mice
Polystyrene nanoplastics drive neuronal senescence via PP2A-B56γ-targeted p-Ebp1Ser335 dephosphorylation-mediated ribosome biogenesis dysfunction
Free radical biology & medicine5 May 2026

Cellular senescence

downin mice1

1 study

LB-100 prevents cellular senescence in mice.
“Pharmacological inhibition of PP2A with LB-100 restored ribosome biogenesis, prevented neuronal senescence, and rescued cognitive deficits and neurodegenerative phenotypes in PS-NP-exposed mice.”
Animalsin PS-NP-exposed mice
Polystyrene nanoplastics drive neuronal senescence via PP2A-B56γ-targeted p-Ebp1Ser335 dephosphorylation-mediated ribosome biogenesis dysfunction
Free radical biology & medicine5 May 2026

More on Cellular senescence

Latest

1 in 12 months

Free Radical Biology & Medicine8 May

Polystyrene nanoplastics drive neuronal senescence via PP2A-B56γ-targeted p-Ebp1Ser335 dephosphorylation-mediated ribosome biogenesis dysfunction

Experiments in miceCellular senescence