LAV-BPIFB4 gene therapy
LAV-BPIFB4 gene therapy has been studied in 2 papers since 2021: none in people yet, 1 in animals, 1 review. The research so far is in animals. The newest paper, Mar 30, 2023: “Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice”.
2 papers study it4 findingsUpdated
- 1 lab in 1 country
- Funders: Fondazione Cariplo and 1 more
- Animals1
What did studies of LAV-BPIFB4 gene therapy find?
4Studies of LAV-BPIFB4 gene therapy measured 4 outcomes; the most studied are Vitality Score (1 study), frailty index (1) and three CpG clock (1).
Vitality Score
upin mice1
1 study
Vitality Score
upin mice1
LAV-BPIFB4 gene therapy improves Vitality Score in mice.
“LAV-BPIFB4 gene transfer resulted in an improvement of the Vitality Score”
Animalsaged
Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice
International journal of molecular sciences
Frailty index
downin mice1
1 study
Frailty index
downin mice1
LAV-BPIFB4 gene therapy decreases frailty index in mice.
“LAV-BPIFB4 gene transfer resulted in an improvement of the Vitality Score with a reduction in the Frailty Index.”
Animalsaged
Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice
International journal of molecular sciences
Three CpG clock
downin mice1
1 study
Three CpG clock
downin mice1
LAV-BPIFB4 gene therapy decreases three CpG clock in mice.
“systemic gene transfer of LAV-BPIFB4 in aged C57BL/6J mice was associated with a significant reduction in the epigenetic clock-based biological age”
Animalsaged
Effects of Human LAV-BPIFB4 Gene Therapy on the Epigenetic Clock and Health of Aged Mice
International journal of molecular sciences
Inflammation
downin reviews1
1 study
Inflammation
downin reviews1
LAV-BPIFB4 gene therapy decreases inflammation.
“Furthermore, LAV-BPIFB4 treatment induced a desirable recovery of the inflammatory balance by mitigating the pro-inflammatory factor levels and enhancing the anti-inflammatory boost”
Reviewgene therapy
The Role of BPIFB4 in Immune System and Cardiovascular Disease: The Lesson from Centenarians
Translational medicine @ UniSa